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    The Guadalupe on Main

    4.6 (294 reviews)
    ModerateBars, Mexican
    Open 11:00 am - 10:00 pm
    Updated 3 months ago

    The Guadalupe on Main Photos

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    THE GUADALUPE ON MAIN ATMOSPHERE

    What's the vibe?
    Hipster
    Casual
    Classy
    Moderate noise

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    Drink Menu
    Beth S.

    We absolutely loved this restaurant! This was our first visit to The Guadalupe on Main and it was fantastic! From the outside, the building has unique historical restaurant flare. Once you walk inside, the decor is absolutely gorgeous. High ceilings with beautiful light fixtures and perfectly executed decorative touches give this restaurant a warm upscale feeling. The food was absolutely delicious. We started with chips and salsa. They give you green and red salsa. The chips were freshly cooked and the salsa were both delicious! The green one was a touch tangier and spicier than the red, but we enjoyed them both. I had the Birria tacos. The meat was moist and very plentiful inside the tacos. The plate came with two tacos, rice, and beans. Let me just tell you these are not your average rice and beans. They were packed with delicious flavor which left me wanting more. My friend had the fajitas and he said they were spectacular! He ordered the steak fajitas. A heaping portion of meat on top of onions and peppers. The service was impeccable and we even got to meet the owner. He was super nice and very grateful we chose his restaurant for lunch. He also introduced us to their executive chef. You could tell they really had a passion for what they do. This place truly is a hidden gem. With such beautiful decor and delicious food this restaurant is perfect for a date night or just a casual lunch/dinner. Check out my heading inside Video, which immerses you in every inch of this gorgeous restaurant. Thank you once again to the entire staff for a very enjoyable meal.

    Denise M.

    We have been here before when this place was Casa Ramos. I guess I expected for them to have made a change, but this place looks exactly the same. It is a very nice looking place with a large fireplace in the center of the wall. Behind the metal cut out screen is going purple lights of the bar. It's kind of a good mix of traditional Mexican and modern decor, leaning more towards modern decor. What I don't like is it feels very echo-y, if that makes any sense. Our server was very nice and very helpful. I ordered one of the specials which was ahi tuna tostadas. There were three of them served on a delicious tostada shell with avocado and black sesame seeds. They were delicious! A friend ordered the street corn which came as a dip with chips. It was really good. I really loved my lunch and the two people with me seem to love theirs. This is a solid choice when you're in Mesa and wanting Mexican food with a bit more upscale atmosphere.

    Fish tacos and carne asada
    Karin B.

    This place was amazing! The atmosphere was inviting and cozy. Staff was terrific. First time here and the recommendations were spot on. Fish tacos and carne asado were both perfect. Worth the upgrade to the corn Tortillas. We had the corn dip appetizer (forgot the name) but it was yummy. Didn't love the salsas which they allowed us to try. Good beer list on tap. I also appreciated that the staff was allowed to dress as they wanted vs some crazy uniforms. Tasteful but happy on all accounts. I would definitely recommend this place and will be back again.

    Ngoc H.

    Love this place. The ambience was chill, quick service, and the food was stellar. Will definitely be back to try other things.

    Chantel Q.

    It was our first time here and they exceeded all of our expectations. Service was a 10/10 the entire time. They check on you, and make sure that you get what you need. It was Friday and we were leaning towards meatless options. My husband had the shrimp fajitas and an old fashioned to drink. He was very happy with his selections. The kids and I had bean and cheese burritos and our youngest had an enchilada. We all enjoyed the chips and salsa. Our daughter and my husband loved the Queso but was a little too thick for me, I really like a creamy queso. Last but not least the vibe and decor of the restaurant is really upbeat and beautiful. I am sure we will be back again, thank you!

    Vice & Virtue & classic margarita
    Lenore B.

    My husband and I practically treat this place as our Friday night hangout. We still love grabbing seats at the bar, soaking in the energy, and watching all the action. We've even met another couple here who've since become friends, that's how welcoming and fun the vibe is. On our most recent visit, we tried a couple of new items. First was a starter: shrimp wrapped in bacon, served on a flat skillet with bell peppers, onions, and a lovely chipotle crema. Absolutely fantastic. The flavors were smoky, savory, and perfectly balanced. We also had the chance to try something from their most recent chef's tasting night, a tuna tostada made with sushi-grade tuna. It came as three tostadas topped with beautifully marinated tuna, and it truly tasted like heaven. It probably won't make it onto the regular menu, which makes me even more grateful we got to experience it while we could. Still one of our favorite spots, and we'll definitely be back (as usual!).

    Also, note the vaulted ceiling!
    Dan L.

    First I have to say I just finished lunch at the Guadalupe on main. The second thing I have to say is I am so full. I probably will not eat for a week. That's a lie, it'll probably be more like 3 or 4 hours. So I was stuck in Arizona getting my car fixed so I was kind of trapped at the hotel with limited food options within walking distance. Of course, I opened up Yelp and found that this place called Guadalupe on main was a literal 5-minute walk from the hotel. I was really craving some Mexican food and was super excited about trying this place out. An easy walk down main Street and there it was on the right hand side. The exterior of the building was very modern and elegant, to be honest I thought I was going to have outpriced myself for lunch. But I was pleasantly surprised when I walked through the door The place is just as elegant on the inside, and when I say elegant I don't mean dressy or overly classy, neat and clean, perfect amount of decor, and a very great open seating area. One of the things that stood out was the giant open window at the far side of the restaurant that had a brick wall going up with this beautiful painted mural on it. Not to mention that there was a green alien skeleton relaxing in there. See my pictures if you don't believe me. I ordered some chips and salsa and a beer, and was not disappointed. Sometimes you never know what you're going to get when it comes to chips and salts at a Mexican restaurant. Best case scenario is that they are homemade. Worst case scenario is they bought them from a grocery store down the street. These were fresh and hot and came with two different kinds of salsas... Red and green. This was especially a nice touch as most places only give you the red sauce. For the main course, I ordered carnitas, if you've read any of my other Mexican restaurant reviews on Yelp, you know that that is The benchmark that I judge a Mexican restaurant by. The carnitas was perfectly cooked, had just the right amount of char on it and was moist and flavorful. The rice and beans were top notch and they gave you a little dab of guacamole on the side to put on your tortillas if you wanted to make a taco. I got to meet the owner, Dirty. Mike, super nice guy, very friendly, made great suggestions and you can tell his heart and soul is in this place. Bottom line? If you are ever are in the Mesa area and looking for some good Mexican food, this is a place you need to add to your list. Everything was phenomenal. And I will definitely be going back again!

    Corn Queso and Chips and Salsa
    Rob M.

    We went for dinner on Friday night at 7:30 pm. Call and make reservations in advance --it was busy! The staff was friendly and perhaps a little short as timing ran slightly long. The interior is one large open room and it was loud and just a touch too bright. The menu offers extensive gluten free options. We ordered the corn Queso, Chips and Salsa, Cheese enchiladas with green sauce, chile relleno, Birria tacos, and steak fajitas. The food was delicious! As luck would have it, we were sitting right next to Van Jones! We will be back.

    Azteca salad--no shrimp
    Crystal Z.

    I saved this place on TikTok to try. We came. We seen. We tried it. Kinda bummed...Let me explain... I ordered the Azteca salad without shrimp. It was good. 7/10 good. Nothing special. The pollo asado--the meat itself was flavorful. The vinaigrette was surprisingly good. My issue was the field greens were full of stems. The portion size was on the smaller size for a salad that was almost 19.00. The fiancé had the asada plate and he rated it a generous 5/10. He said the meat lacked flavor. The refried beans tasted like canned and the rice was dry. He was upset he spent 25.00 when he could have gone to Chipotle for a steak bowl. The chips and salsa were...just chips and salsa. A bit small on the portion size for chips. The red salsa was mostly a tomato base with no spice. The green salsa was the better tasting salsa. The best part of what we ordered were the cocktails. We both enjoyed our drinks. I had the Jackoloupe Cowpoke and the boyfriend ordered the Thirst Trap. We both would rate our cocktails an 8/10. Service was ok--she forgot our straw and never came back around to ask us if we wanted to order another cocktail. We probably would have if she had asked. Overall--first impression was underwhelming and overhyped. The food definitely was not giving authentic Mexican and was very average at best but the cocktails were decent. To drive 15 mins for Mexican food and cocktails there are other options but we can at least say that we tried it.

    Decor
    Savannah R.

    Okay..WHAT is this hidden gem?! If you haven't been here, stop what you're doing and get over here now. Guadalupe on Main is a Sonoran style Mexican food spot giving off upscale moody upscale vibes. Upon entry, you'll walk around to the main dining room. You will immediately see that moody feel with the dark painted walls & mid century modern furniture. Our server made his way around and was very friendly. We were a group of 8 with small children and he was patient and welcoming with all of us. We started off with chips and salsa, which was nothing to rave about. Once our food hit the table, it was so beautifully and elegantly plated. Everyone enjoyed their food and I especially loved mine. I opted for the chicken mole enchiladas and they were SO GOOD. The mole was as authentic as my grandmothers and each rolled into a handmade corn tortilla and stuffed with just enough filling. For dessert, we had the churros with chocolate and they were served warm and soft. Around the corner from the dining area, you will find a small sports bar and make way your to the secret door for a speak easy! You'd never think it was a door, it is made to lol like a little library! Honestly I think it's a tattoo shop behind there I'm not sure what I was told but it closed unfortunately so we couldn't go. So happy we found this place!

    Excellent Flan for desert.
    Art H.

    9/28/25 Second visit. Parking 5/5 Early dinner-4:30 pm. Easy parking on off peak visits in private lot. Atmosphere 5/5 Beautifully done in a modern contemporary Latin design. Service 5/5 We were greeted immediately and offered our choose of table. Our server Mia joined shortly after being seated. We let her know we were ready to order and she did. Very friendly. We ordered iced teas, two Steak Fajitas meals, pan fried jalapeños, two Barria Tacos Ala cart. Mia asked if we'd like to have our tacos first. After dinner we ordered their Flan. Food 5/5 Everything we ordered was Guadalupe delicious! Way too much food so we brought home leftovers for another meal! Entertainment 5/5 We had a DJ for our entertainment He played R & B, it was a nice show. Eat well my friends-SYOY

    Pattarawadee K.

    I would give them 5 stars if their chip is not sticky and chewy besides that theirs foods is wonderful

    My drink was flaming!!
    Monica S.

    Came upon this place so randomly. I love Mexican food and always am craving a good margarita. Hands down; the best of everything!! A Cadillac marg so good, that is the reason I will go back. A daily special; an Ahi Tuna Tostada. My husband got bacon wrapped shrimp. What words could I use to encourage you to try this place out? Exceptional-Memorable-Repeatable I'll be going back before my vacation ends

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    An amazing locally owned and operated restaurant that makes a point to treat you like family. Food and drinks are top tier.

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    The Guadalupe on Main - bars - Updated July 2026

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