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Alchemy Choose Thy Poison

4.8 (213 reviews)
Closed • 4:00 pm - 10:00 PM

By appointment only

Updated 2 weeks ago
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ALCHEMY CHOOSE THY POISON ATMOSPHERE

What's the vibe?
Casual
Trendy
Intimate
Outdoor seating

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Reviews With Photos

Ceviche  Negro
Jiansen W.

Alchemy Choose Thy Poison is serving delicious modern Mexican cuisine. AMBIANCE The charming dining space is Al fresco/outdoors, tucked between brutalist architecture, concrete fortress, Hotel Narcissus. Mosquitoes and flies are unfortunately afoot this humid and hot summer's night. SERVICE Staff was friendly, helpful, and attentive. DRINK New season drinks arrived. I was bummed to find a prior drink gone - 海道 (Kaido) Gin or vodka, kombu-celery syrup, lime, dry vermouth, saline, olive-herb oil. 4/5 alchemy tonic: sweet citrus tonic separated by sparkling water 4/5 bloodstone: sweet and hibiscus forward, didn't taste basil 3.5/5 ABUELITA'S old fashioned: very chocolatey, spirit forward FOOD 5/5 CEVICHE NEGRO: SNAPPER, love the RECADO NEGRO (SQUID INK, TAMARI, & CHARRED PINEAPPLE ASH) 4/5 CREMA DE POBLANO ROASTED POBLANO AND CORN BLENDED INTO A CREAM soup, topped with MORITA OIL, QUESO FRESCO, CHILE ANCHO. Served with SOURDOUGH CRAFTED FROM HEIRLOOM BLUE CORN (nicely crisped, not blue) 5/5 CRUDO: SEARED TUNA paired perfectly with the sweet and tart POMEGRANATE SALSA MACHA 5/5 ZARANDEADO Tender, flavorful, tail-on ADOBO-MARINATED MEXICAN SHRIMP, BLISTERED veggies

Bonesmoke.. if you like negroni this is for you
Van L.

I came w very high expectations since the reviews were so great but it did not hit the mark. The overall experience was ok. Service was just one waiter. I felt bad for him but thank goodness it was a small restaurant. Our party of 4 was seated at the same size table as a table for 2. Felt so squished since we ordered the entire menu to sample. Wish they had a larger table. Food and cocktails were a hit or miss. Overall I'm glad I tried it but most likely will not return.

Seating
Julianne B.

SUCH A GEM- the food, the service, the vibe. First, the food- we absolutely LOVED everything we had, flavors were excellent! Our can't miss is the smoked tuna empanada. The entire staff was incredible, warm, like we were part of the family. Then, the location - I love the outdoor dining vibe and all the art. It was a little hidden in the most fun way.

Braseado braised beef
Valerie T.

What a secret surprise hidden within the courtyard of a boutique hotel! Keep in mind, street parking is the only option, but trust me it's worth the hunt. As you walk up, you'll see huge windows looking directly into the restaurant's kitchen, where all the magic happens. You may even spot a restroom along the way and wonder, "Am I actually in the right place?" Trust me--you are! We made a reservation, and the team was incredibly accommodating when we ran into some traffic and arrived later than expected. Since everything on the menu sounded amazing, unique, and completely different from what we normally order, we decided to go with the tasting menu, aka the Weekly Ritual. We each chose different dishes so we could try as much as possible--and I'm so glad we did! The drinks! The cocktails were just as creative as the food. As a whiskey lover, I had to try the Whisky Sour, aka Wolfsbane--Earl Grey, citrus, dark tea, and bright acid with what they describe as "the calm before the burn." Well... I loved it so much that I couldn't stop ordering them until we officially shut down the restaurant. Oops! Now, the food! For the first course, we tried the Baja Caesar and Crème de Poblano. The soup was such a surprise--the heat slowly creeps up on you, while the Caesar may look simple at first glance, but it was an absolute explosion of flavor. For the second course, we chose the Ceviche Negro. Its striking black color doesn't prepare you for the bright, vibrant flavors of the fruit and perfectly prepared fish. We also ordered the Smoked Tuna Empanada, and honestly, I haven't had anything quite this memorable since some of the incredible food I experienced in Peru. It was simply a delightful little pocket of magic. The third course brought braised beef with butternut squash purée, perfectly prepared Brussels sprouts, and an incredible mole. We also couldn't pass up the squid ink-braised oxtail. We never sleep on a chef who wants to reinvent the wheel, and this was exactly the kind of creativity we were hoping for. And, of course, we had to finish with both desserts. The perfect ending to an incredible meal just the right amount of sweetness to close out the night. We truly couldn't have asked for a better experience. From the incredibly creative food and cocktails to the welcoming and accommodating staff, every part of the evening felt special. A huge thank you to the entire team for a phenomenal experience! We'll absolutely be back sooner then my wallet wants.

Verde Zero Proof
Lily Ann P.

Finding the entrance was probably the hardest part of our evening My husband and I walked up wondering if we were even in the right place, but luckily our server, Alex, spotted us outside and got us seated right away. From the start, Alex made the experience memorable. You can tell when someone genuinely loves the food they're serving, and his enthusiasm was contagious. Every recommendation came with thoughtful details, and honestly, he didn't steer us wrong. His top recommendation was the Oxtail Tetelas, and wow! This ended up being my favorite dish of the night. The sauce was absolutely incredible, rich and flavorful without overpowering the dish, and every ingredient worked together perfectly. As someone who has never considered Mexican cuisine my go-to choice, this dish completely changed my perspective. It was comforting, creative, and packed with flavor in all the right ways. My husband ordered the tuna empanadas, which were being made fresh at the time, and after stealing a few bites (as any good spouse does), I can confirm they were equally delicious. Fresh, light, and beautifully prepared. For drinks, I went with the Verde Zero Proof. It wasn't my usual flavor profile and had a bit more spice than my taste buds typically enjoy, but that's more of a "me" problem than a criticism. If you enjoy a little kick in your drinks, you'll probably appreciate it much more than I did. The restaurant itself has that cozy hole-in-the-wall charm that makes you feel like you've discovered a hidden gem. The vintage decor creates a warm atmosphere that's perfect for date night, and as dog parents, we especially appreciated that the place is dog-friendly. That was actually one of the main reasons we decided to give the place a try, and we're glad we did. Great food, great service, a cozy atmosphere, and a few surprises along the way. We'll have to come back to work our way through more of the menu

Crudo
Deb N.

I was treated to this place for my birthday and I have to say it might've been one of the top five meals I've ever had in San Diego so unique and where it's at under an overpass in a concrete building, but it has so much character so much artistic I don't even think there was music because I didn't notice any Tables very intimate one server and the food wow our server helped us pick options for the table and did not steer us wrong all night . This place is hard to get reservations because there are only seven tables but it's worth the wait so find a time and make sure you go.

Gold bar
David Z.

This was a very cool experience. Highly recommend making reservations as they only have a couple of tables inside. We tried a couple of the menu options and everything we ordered was delicious. Our server was extremely friendly and explained everything.

Crudo  SEARED TUNA, CHARRED HIBISCUS SALSA, CUCUMBER, AVO SALSA, PICKLED GRAPES, POMEGRANATE SALSA MACHA, FURIKAKE, CHIPOTLE AIOLI
Karmen P.

Every once in a while you stumble onto a place that completely catches you off guard. ALCHEMY was one of those places. From the outside, you'd never expect what's happening here. It's this hidden little outdoor nook tucked into the middle of urban grit with eclectic art, concrete walls, moody lighting, and this weirdly cool energy that feels equal parts underground gallery and secret dinner party. Then the food arrives... and suddenly none of your surroundings make sense anymore because the dishes coming out of that kitchen are on another level. The menu is small and intentional -- which I personally love. Every plate felt thoughtful, layered, and beautifully executed instead of overloaded with gimmicks. The mole sauce on the braseado was insane. Deep, smoky, rich, velvety... one of those sauces that makes the entire table go quiet for a second. The seared tuna crudo was fresh and balanced perfectly, the crema de poblano was silky and comforting, and even the cocktails felt crafted instead of just poured. And the service matched the vibe perfectly -- warm, attentive, relaxed, Just really good food, cool atmosphere, and people who clearly care about what they're doing. Honestly one of the most unexpectedly memorable meals I've had in a long time.

Smoked Tuna Empanadas. IG @mel_foodie_ventures
Melanie P.

Saw this place through IG and had it saved to take the girls out for dinner. This place is tucked away in a patio space next to an Airbnb and a nearby apartment complex. It was small and intimate with interesting art throughout. I love the open, airy but private vibe of this place. Recommend making reservations since this is a small place but you may score some seats if you come early enough. We came during happy hour which was half off the entire happy hour menu! They didn't skimp on the food and cocktail selections which happens a lot at other establishments. What I ordered - Baja Caesar - Instead of romaine, this came with spring greens. It still worked, the dressing was lightly coated and it was a refreshing start to my meal. Bloodstone with gin - A pretty drink that was delicious to drink! Ceviche Negro - Love the freshness of the seafood and the squid ink sauce! One of my favorite dishes. Smoked Tuna Empanadas - I had to order another one! It was that good! Never had smoked tuna in empanada form and this was absolutely fantastic! The delicate crisp of the empanada paired with the smoky flavor of the tuna is another dish that you must put in your rotation! Oxtail Tetalas - The meat was tender and masa was perfectly crisp! Zarandeado - This one was a little too salty for me, which was a sentiment also shared with those in my group. Braseado - This also was super tender! Loved the mole, which was smooth and flavorful. Dessert - Rose Tarts - A pretty handheld dessert that was tart with raspberry flavoring. This was sweet but not overly sweet. I'm not a fan of fondant frosting, so it wasn't my fave. Tres Leches Cake - This dessert is the one to order. Perfectly moist and soft, this is the perfect ending to the night. Loved the experience, we got a random cat that decided to visit us while we dined :). There were quite a few flies around, so this took away some of the ambiance. I would definitely return for their elixir hour!

Short rib and butternut squash puree  and charred Brussels sprouts

The food was delicious well thought out and presentation was chefs kiss!:) overall service was amazing shoutout to Isaac for making my first time experience awesome he knew a lot about what I would like according to my preferences and cared I truly love the energy and ambiance there! The decor is medieval mixed with an aztecan vibe is what I would call it I like each and every crafted element in the design and intentional details of the overall flow and vibe the

Willis N.

Best elevated Mexican food I ever had. The restaurant was situated in a very strange setup lol it was quite literally a hole in the way alleyway seating embedded in a living complex. That in mind, every single dish shook what I knew about Mexican cuisine. Every bite, a bold tangy and bright fiesta to the senses. They sure do love their mole here. Their drinks were great too. I don't typically order spicy alcohol but our server was very enthusiastic, knowledgeable, and polite about his recommendations so I couldn't refuse. When even the servers care about what youre eating/drinking you know its gon be fire

Courtyard where the restaurant is located.
Jessica A.

We did the tasting menu and really enjoyed it! I had the crema de poblano, smoked tuna empanadas, and the braseado. The location was very cool. Staff were super friendly and gave great recommendations. I would absolutely go back again.

B&B Building
Jeng L.

While searching for an up-and-coming Mexican restaurant for a family trip to San Diego, I discovered Alchemy and was immediately drawn to photos of its photogenic dishes. Alchemy is a hole-in-the-wall spot with big ambitions, working to transform both the neighborhood and expectations of Mexican cuisine. The restaurant is set up in the courtyard of a small B&B. Aside from the kitchen and restroom, all seating is outdoors, with about half a dozen heaters keeping guests warm. I suppose San Diego seldom rain except this December. While waiting for food, you'll notice interesting art installations (particularly snakes) and white sage, burned wood scattered throughout the space adding to the experience. The flavors absolutely live up to the hype. Eddie--the owner, chef, waiter, bartender, and janitor all in one--was constantly moving and humbly delivered the best meal we had in San Diego. My two favorite dishes were the snapper ceviche and the huarache. The ceviche, completely coated in black ink, was extraordinary. Its depth of flavor came from a thoughtful mix of cucumber, mango, onion, cilantro, avocado, chiltepin, and charred pineapple ash. The huarache featured generous portions of braised beef, paired with beans, pickled tomatillo, and other fresh elements that brought balance and brightness to the dish. The food at Alchemy isn't typical Mexican fare, it is designed to feel like something you'd find in the chef's hometown of Mexico City. I highly recommend visiting Alchemy if you're looking for a memorable and exploratory dining experience while in San Diego.

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Food, cocktails service, ambience - everything is absolutely amazing here. I got to spend the most memorable bday evening here

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Alchemy Choose Thy Poison Reviews in Other Languages

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This was such a cool bar with very nice staff…read more It's easy to find, street parking was a nonissue, and they have a huge selection of cocktails with a decent selection of mocktails as well. I love their menu design. It gives a lot of attention to each drink with a clear description breakdown along with the level of alcohol meter. A lot of the drinks are STRONG and their presentations are magnificent.

We had such a great experience at this space themed bar! One thing that I would make a note of is…read morethat we did make a reservation for 10 pm on a Saturday night, but still had to wait in a very long line out the door for a good 15 minutes. We were confused, along with many other folks in line. I think they were just preparing their tables way longer than expected. Other than that inconvenience, the bar itself was beautifully decorated and very on-theme. The drinks were very much giving "tiki bar but in space" and were veryyyy strong. They have an alcohol strength spectrum on their menu so you can guide yourself through the drinks. We got drinks that weren't even on the strong side of the scale and they were still pretty strong. This would be a great place for a pregame for sure! They even have some food and seasonal soft serve other than their normal drinks. Overall, great service, strong drinks, and fun vibes. Perfect place for a pregame!

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Noble Experiment - Spiced banana flip! Delicious!

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4.5(1.9k reviews)
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Drinks are hit and miss. No menu bar is more gimmicky than anything…read more I'm sure there's some set menu that the bartenders just play off of and quality of the drinks really really just depends on who's your bartender. First round was great, not exactly what we ordered but still quality cocoktail. Second round was not good at all. And especially not what we ordered lol The wait on off days can be 5-10 minutes. Busy days it can be 1-2 hours. Drinks: 5/10 Service: 6/10 Atmosphere: 7/10 Value: 4/10

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False Idol - Reserve Mai Tai

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4.4(1.4k reviews)
2.0 mi•Little Italy
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They don't serve food but they are connected to craft and Craft & Commerce which has good food…read more The staff is awesome I've never had a bad experience and when visiting for a special occasion they've always gone above and beyond to ensure we have a good time! The decor is incredible it's absolutely a must see for all tiki fans and anyone who loves a heavily themed bar!

This is a very small but beautifully decorated tiki bar inside the Craft & Commerce restaurant. I…read morerecommend making a reservation but you can also try walking in (you may be allowed access but may not get a table, so be prepared to stand). The place is not exactly hidden; there is a host stand near the entrance. For what it is worth, the parking lot next door to False Idol and Craft & Commerce should be renamed Butch Cassidy, not because of the entertaining movie, but because it charges highway robbery rates. We paid $40 on a Friday night. That is...outrageous. The menu at False Idol is long and delightful and the drinks are delicious. As far as I can tell, none of the drinks are blended, so sorry for you Pina Colada fans, which includes me. They also offer three mocktails. We tried a Mac Nut Chi Chi (macadamia based) and a Chi Breeze mocktail (also macadamia based). They were both very nice. I appreciated the detail in the menu. If you want stronger and boozier drinks, they are available. If you want something lighter, they have that, too. Most of the drinks seemed reasonably priced. The lighting and music were excellent. When someone ordered a shareable "bowl" drink, loud volcano rumbling noises played and the lighting flickered. That was fun. As a tiki fan, I would return, but I would never, ever park in that evil thieving parking lot next door again.

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Books & Records - Table setting

Books & Records

4.3(429 reviews)
2.1 mi•Banker's Hill
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Really delicious food but the portions are so tiny! So just a fair warning. Quite busy on a Friday…read morenight but we luckily made reservations and got seated maybe ~10 minutes after checking in. Food: - Flat iron steak: delicious and super tendy with a nice crust. Came with an arugula salad - Fish of the day: today was rock fish with a creamy panang/thai sauce and it was DELICIOUS - Duck: my table's favorite dish. You can make your own tiny tacos and the macha chili was seriously the best thing ever - French fries: nice horsestring fries, cant go wrong - Tuna crudo: super light and citrusy and flavorful, but only like 5-6 pieces - Chicken skewers: this honestly fell really flat. Would not recommend, i'd say it's the worst thing on the menu and surprisingly fell short. Doesnt feel like it belongs on the menu. - Brussel Sprouts: really good and unique with a peanut butter sauce - Mac and cheese: yummy but nothing special Overall was a great experience but I'd probably only come here on special occasions. Their drinks were also fantastic - the cantaloupe was super tasty. Shoutout Ola for being the best waiter!

New breakfast spot for me! Super cute decor. Love the vibe here. Bar seating looks cozy and open…read more I love the books & records they have displayed. Patio seating also very cute. Lots of inside seating. Our waitress Allie was super friendly. We had the short rib hash & the florentine Benedict. Both were delicious and the presentation was great. Visited on a Sunday morning and they weren't terribly busy. Looks like they have music on Saturdays. Not a huge menu but good options. We found parking on the street. Try it! Super cozy here.

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Good Enough Cocktail Club - OST Cocktail in the making

Good Enough Cocktail Club

4.5(40 reviews)
2.0 mi•Little Italy
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Private events
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555 those are great numbers & the address to this establishment. Came for one last drink before I…read moreleave. It's been great, fantastic Little Italy & this spot is perfect for afternoon easy breezy vibes. The decor is inviting & the music is chill, relax with a laidback groove. The bartenders on point with this drink. I ordered the MMM. . . Food. It's more sour in the Whiskey Rye sour category Love the record collection. Wanna just hang after dinner, this is your spot. I'm including the screen shot of the music playing right now. Bravo bartender/DJ You can also order & pay by barcode. How convenient when the night gets busy. Will definitely be back.

I came here on a Tuesday around 5 PM, just as they were opening. They have patio seating right next…read moreto the bar as well as a really cute indoor seating area if you prefer to escape the heat. The bartender was fantastic. She was friendly and on top of it. She appeared to be the only one working, yet there were already eight or nine people on the patio. Even so, she stayed on top of everything, and we never had to wait to place an order or receive our drinks. I ordered: * Static Age: This refreshing green cocktail is served in a tall Collins glass and is made with vodka, matcha green tea, vanilla, yuzu, and seltzer. It wasn't overly liquor-forward, making it light and perfect for a warm afternoon. * MM..Food?: Served in a cocktail glass, this drink features masala chai rye whiskey, vanilla honey, ginger bitters, lemon, and egg white. While the flavor combination sounded interesting, it ended up being just okay. It wasn't bad, but it didn't really stand out and wasn't my favorite of the two. *Espresso Martini: this was also enjoyable and not too sweet. Overall, this is a fun spot with a great atmosphere. The courtyard has plenty of energy, live musicians performing, and several restaurants surrounding the area, making it a great place to relax and enjoy a drink. Although none of the cocktails I tried really stood out or have me rushing back for more, it's a nice spot to stop by.

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Charade - In house artist during the jazz performance

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4.5(89 reviews)
1.9 mi•Banker's Hill

A hidden oasis located in Bankers Hill. This speakeasy curates everything from live jazz,…read moreburlesque, and a cultivation of all things off beat and different. Cass the head honcho of this outfit ensures all patrons are welcomed and topped off with their favorite beverage. Bask in the glow of the red lights and velvet curtains and vibe out for a while.

As the self-appointed king of speakeasies, I'm back at it with another one. After having dinner in…read morethe area, we stopped by Charade for some drinks on a Monday night. I parked on the street close to the dinner spot I went to and then walked over to Charade. Ambiance (5/5): Charade is a speakeasy so here's your clue. It's located inside Balboa. Look for the room with the arcade games and you're on the right track. Once you enter the speakeasy, you'll immediately be impressed with the old school charm. It seats roughly 20-30 people and there's a bar on one end and a stage on the other end. Old school red curtains add to the vibe. And here's the best part. On Mondays, it's jazz night. Local musicians will play which makes for a great time. Service (3/5): There was one bartender working when we were there. Overall, she provided pretty good service. There was one comment she made which rubbed me the wrong way but no biggie. Food (N/A): I had dinner prior so were on a liquid diet. I did notice that they have a few snacks available like popcorn. Drinks (4.5/5): When you think of speakeasies, you think of elevated cocktails. I look for creativity and an interesting blend of flavors and ingredients. The menu here, while not huge, has some interesting options. Outside of the menu itself, the prices are reasonable (especially for California). And they make you stiff drinks which is always appreciated. Taking into account the cocktails and the ambiance, Charade is an awesome laid-back speakeasy. Make sure to stop by on a Monday for jazz night. That takes things up a notch.

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Alchemy Choose Thy Poison - mexican - Updated October 2026

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