**NOTE:**
The following is not opinion but a factual account supported by official medical records and publicly available guidance on antibiotic-related risks.
**SUMMARY:**
After a routine root canal and being prescribed **clindamycin immediately after amoxicillin**, my wife (age 60+, with a heart condition) developed **C. difficile colitis**, a potentially life-threatening and possibly lifelong condition. She now suffers frequent relapses, ongoing health issues, and we've had to radically alter our lives as a result.
**BACKGROUND:**
Initially, my wife was given amoxicillin post-root canal. When she reported lingering pain, the dental office prescribed clindamycin -- without performing a risk assessment, despite her age, heart condition, and recent antibiotic use. According to CDC and major hospital guidelines, clindamycin carries a **high risk of causing C. difficile**, especially after prior antibiotic use, due to gut flora disruption.
Clindamycin was finished in late April. By mid-May, she became violently ill: severe diarrhea, 102-104°F fever, dizziness, and dehydration. She was admitted to the ER and later diagnosed by her physician with **C. difficile colitis**, confirmed via lab testing. Kaiser doctors immediately started her on Vancomycin (another antibiotic) and probiotics.
While she briefly recovered, **C. difficile flared again** within days -- a well-known recurrence pattern with clindamycin-induced infections. Once a second flare-up occurs, recurrence rates jump to over **60%**, often resulting in chronic relapsing colitis. My wife has now had **persistent diarrhea (5x/day)**, ongoing weight loss (15+ lbs), dehydration, fever, and ER visits -- spanning **6 weeks**.
We've had to cancel vacations, family events, and put major life plans on hold. I was laid off in April and stopped job hunting to care for her full time. She's missed 3 weeks of work. We've delayed selling our home, and reconsidered retirement plans. This entire health crisis was **completely avoidable** with appropriate caution.
After informing the dentist of the diagnosis, he expressed surprise but offered no explanation or follow-up. He has **not contacted us since**. That silence, combined with what we believe was a lack of risk screening before prescribing clindamycin, is deeply disappointing and has had devastating consequences.
Prescribing clindamycin immediately after another antibiotic -- especially in a high-risk patient -- **requires clear justification, informed consent, and discussion of alternatives**. It is widely known that C. difficile infections can begin **weeks after** the antibiotic is finished, especially with clindamycin. This case is a sobering reminder of how critical antibiotic stewardship is.
My wife is now dealing with a chronic, possibly lifelong condition -- from what should have been a routine dental follow-up. We share this to help others avoid the same harm and to encourage all healthcare professionals to take antibiotic risks seriously. read more