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    Isotope Comics

    4.6 (249 reviews)
    ModerateComic Books
    Open 11:00 am - 5:00 pm

    Isotope Comics Photos

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    Denise C.

    I had never walked around this street and seen this comic store. It was open on a Covid day(late descent). The bougie deli next door was snapping at me, so I got to this storefront and looked inside and saw comics. The layout and selection was unique. It's two people that run the comic store. It's European modernist or anime and it's a different take on comics. I needed some recommendations and he showed a few. Try $10 or $15 or $5. I picked a comic book(brochure size) that I had not seen. It seemed rare and I liked picking comics. San Francisco is a comic book and collector's town. You can find some interesting items here. They don't have figurines or accessories like t-shirts and gadgets. He has clearly read through comics and elaborate advanced writing for comic books and the illustration quality is understood. The guy is friendly and wearing a funny suit.

    Ended up buying The Fade Out thanks to a run down with the worker.
    John C.

    This review is based upon a visit during COVID-19 times. I had heard/read great things about this shop and I was very excited to visit it during my wife & I's first vacation child free. I had read that they were open even with Covid happening. Super excited, three hour drive and a two mile walk.... sadly they didn't allow you inside. The wife wasn't the happiest that I dragged her this far for "nothing". However the guy/owner? James? I believe, was amazingly nice and informed me that another shop about a few blocks away was open to indoor shopping. I didn't drag the wife to that location, instead I talked with James. I asked if he carried any floppies/keys or CGC comics which he kindly informed me that another location had what I was looking for. But again I'd rather stick to this location. James brought out a few different trades for me to check out and gave me a run down on each story. Letting me know what was a complete story and/or what I may need to buy. I was blown away by his kindness and his knowledge. I would love to shop at this location more often. If I was a local this would be my place just because of this gentleman. Long story short I ended up enjoying my visit even if it wasn't what I had planned/hoped for. I will return whenever we come back the the bay and when Covid is hopefully done with.

    Toilet museum!!
    Alley R.

    James is AMAZING, as is his store. He gives a great talk on his toilet seat collection, which he rotates. The store has pretty much everything you could want in a comic book store. He is dog friendly. So bring your pups. His prices are on point and the store is super clean and uncluttered. He was also quick to answer the phone and give information so we could visit!

    My own published comic release entitled Hikikomori Nation on display at Isotope!!!! Pick up a copy there while supplies last...
    Isabella A.

    Wonder why I never knew about this place before!?! Been living independently in SF since 2002(native also btw),and weird how this place was always underneath my radar. Better late then never I guess! If you are a local comic book creator,I definitely recommend this place. The owner James knows his stuff,and is a big supporter of indie comics. My favorite new comic shop in town for sure. Good selection of titles also,both major and indie. 5 stars from me!!!! :)

    One of the free comic books I got 5/3/14
    Ann L.

    Went to Isotope Comics for FREE Comic Book Day Sat 5/3/14. It's next to Fatted Calf in Hayes Valley - Fell and Gough. A storm trooper outside greeted me. I liked that. Lots of people were there. I asked the owner where the FREE Comic books were and he told me on the table, take as many as you want, but then know a kid might not get any. I took a few. Next time I gotta look through each one because lots were just ads / sneak peaks of comics you have to buy. Just ok for me, but I'm not a huge comic book fan.

    Captain B.

    The guy that owns and runs this place is so incredibly friendly and cool. He replied to me over yelp quickly and ordered a comic for me they didn't have in stock. And he held the comics for me on the side. Sure, some comics might be a little cheaper online, but this place has a soul that's worth visiting.

    Johnny G.

    I have stopped collecting monthlies after 30 years, but I could not go near SF without stopping by Isotope. I thought I would pick up some issues of Supreme (64-66) by Erik Larsen. James was and still is the character I remember him as from my previous visit. He's inviting, excited, and will do whatever it takes to make a customer happy. I was able to get 2 of 3 books (65 & 66) that I was looking for, and he pointed me to another comic shop a few miles (?) away. I just loved this guy's energy. He always enjoys what he does, and it's a refreshing change from any expectation one has when visiting a comic shop outside your own sandbox. It's a killer comic book store that you MUST visit if you are in the SF area. If this is YOUR local comic book shop, then I really envy you. Keep up the good work James!! (Oh, there's a no plastic bag in effect in the area, and James sells his bag and boards in bulk only, so I had to be really ginger with my newly purchased issues a few blocks to the car. So, I guess one should already have their bags and boards with them when they visit!!)

    Short line for a daytime signing with Saga writer Brian K. Vaughan in their upstairs space.

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    10 months ago

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    2 years ago

    This place is amazing. Such a great selection of comics, and wonderful recommendations.

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    5 years ago

    Great selection, customer service is above and beyond and James, the owner is super friendly and knowledgeable.

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    Ask the Community - Isotope Comics

    Do you carry Spawn volumes, and?

    You bet! It looks like we just have SPAWN: OMEGA at the moment. Let us know if you’d like us to set a copy aside!

    I am looking to sell several hundred comic books from the early 1980's. I have no idea their value.…

    Isotope doesn't buy collectable comic books.

    Do they buy comics?

    Nope.

    View All 4 Questions

    Review Highlights - Isotope Comics

    James was so excited for talking about comics, introducing me to so much more comic art I never knew existed.

    Mentioned in 92 reviews

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    Isotope Comics - comicbooks - Updated May 2026

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