I stayed at Hotel Alwyn for a long weekend in Prague. The rooms are decently sized and quiet - the breakfast spread is excellent offering hot eggs, sausages, cold cereals and yogurts, cold meats, cheeses, danishes, etc.
It's a bit of a long walk (about a mile) to old town, but if you're the type to get up and go for the day and don't need to chill back at the hotel multiple times through out the day, this won't be an issue at all. There is a street car that stops near by and ubers to old town are fairly cheap. read more